BUNIUM PERSICUM PDF

Bunium persicum World Plants: Synonymic Checklists of the Vascular Plants of the World (version Mar. ). In: Roskov Y., Abucay L., Orrell. Bunium persicum (Boiss.) Fedtsch., Rastit. Turkestan. Wolff in Engler, l.c. ; Rech. f. & Riedl, l.c. Vern., “Kala Zira”. Carum bulbocastanum auct. Bunium persicum (Boiss), called in Persian as “Zireh Kohi” belongs to Apiaceae family, which widely grows in the southeast of Iran (6). The plant seeds have.

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Humans have been using plants as natural medicines since prehistoric times. Bunium persicum is a rich source of oils with different biological activities such as antioxidative and antimicrobial activities. The aim of this study is to evaluate the antihematotoxic and antioxidative effects of the differential extracts of B. This study was performed on animals, which were divided into several groups: We measured the concentration of free radical [reactive oxygen species ROS ] and hematological parameters as blast cells from the tibia persium femur in different groups.

The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B. Moreover, there was an imbalance in hematological parameters in untreated and treated groups with a correlation between free radicals and plant extract administration.

These findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B.

Plants have been used as medicines buniym the dawn of civilization [1]. Bunium gunium is a high-value herbaceous spice of the parsley family Apiaceae persicjm as a spice to add flavor to certain dishes and delicacies, persjcum bakery perennial aromatic and medicinal umbel lifer [2].

Essential oils found in B. Oxidative stress can lead to a number of human diseases such as atherosclerosis, inflammatory diseases, neurodegenerative disorders, and different types of cancers [9,10]. Wan and Winn [11] have reported that ROS play a major role in benzene-mediated fetal hematotoxicity bunim mice. These oxidative stresses are encountered by antioxidant compounds that prevent or delay the peroxidation of fats.

Different types of synthetic antioxidants such as butylatedhydroxytoluene, butylatedhydroxyanisole, propyl gallate, oersicum tertbutylhydroquinone are used as additives in food industries. These antioxidants, however, have been reported by researchers to be potential carcinogens and can cause external and internal bleeding and finally death owing to their effects on the blood coagulation factor [12]. Because of the hazardous effects of synthetic antioxidant additives, consumers have shown an increasing tendency to use additives from natural resources such as plant essential oils in foods, beverages, and cosmetics.

The seeds of B. In the present study, we examined the effects of different fractions of B. To achieve this goal, different seed fractions of B.

Plant materials seeds were purchased from a market in Rawalpindi, Pakistan. They were cleaned, washed, and dried under the bhnium. The seeds were then ground into fine powder with a grinder.

Bunium persicum – Useful Tropical Plants

The solvent containing the crude extract was filtered with a Whatman filter paper Number 1 and evaporated under reduced pressure using a rotary evaporator and allowed to dry at room temperature. The maceration process was repeated three times.

The dried extract obtained was suspended in water and extracted with hexane, ethyl acetate, and butanol solvents subsequently using a separating funnel to obtain the ethyl acetate, butanol, hexane, and aqueous fractions. The solvent from each fraction was evaporated and allowed to dry.

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This study was carried out with the approval and under the strict guidelines of the institutional ethics committee for the handling of animals. One group was designated as the control normal group Group Cwhereas the other five groups A, B, D, E, H were injected intraperitoneally i.

After the 40 th day of injection, the weight of each rat was accurately measured, and rats were treated as follows: The dosages were given as i. Table 1 shows the treatment schedule. After the treatment with plant differential extracts was completed, all rats were sacrificed on the 10 th day by decapitation, and blood was collected and sent to North Western Laboratory Peshawar, Pakistan, to determine the blood parameters: The bone marrow was collected from the both the tibia and the femur within hours after the rats were buniuum.

The pdrsicum were cleaned from the tissue, and the tips of each bone were cut down from one side and flushed out from the other side with gauge needle with phosphate buffer saline into a falcon tube. The flushing was repeated several times until the bone turned pale.

A drop was made from the cell suspension into a clear slide and allowed to dry.

Bunium persicum

The air-dried smears of bone marrow aspirate were fixed in methanol for 8 minutes. The slides were then immersed in Giemsa stain for 10 minutes and washed with distilled water to remove the extra stain. To make standard solutions, in 0. Persifum and R2 were mixed at a ratio of 1: Hematological parameters in various study groups treated with differential extracts of B.

Effect of differential fractions extracted from the seeds of Bunium persicum on different hematological parameters compared from CBC results and free radical concentration in serum. Groups A, B, E, and H were administered intraperitoneally i.

Groups C and D were assigned as vehicle controls and were only injected i. A Percentage of basophils in different groups. D Numbers of platelets. G Level of ROS in different groups.

Variation of differential blood parameters nunium comparative analysis of ROS mean values among normal control, disease control, and treated groups. Elevated persicym of free radicals buniun considered toxic for biological systems. The level of free radicals in the hematotoxic group Group D was high compared with that of normal rats in Group C Table 2. Large numbers of blast cells were observed in the disease control group as compared with the normal control group. Bone marrow smear stained with Giemsa stain.

The blast cells are indicated by an arrow in each figure. C Blast cell in EFT. D Blast cells in BFT.

Regulation of ROS level is essential for maintenance of normal populations of hematopoietic stem cells and their differentiation in normal hemopoetic cell lines [17,18]. ROS in cancer can be targeted by the use of antioxidant molecules to suppress the high levels perskcum ROS [19]. However, researchers have shown that these antioxidants are potential carcinogens and can cause internal and external bleeding and even death owing to their effects on blood coagulation factor.

Because pericum these health-threatening effects of synthetic antioxidants, it becomes crucial to explore natural antioxidant compounds as safer substitutes. Based on the antioxidant activity of B.

In the present investigation, our finding of increased ROS level compared to the normal group is in agreement with previous reports. Surprisingly, we found decreased blast cell populations in EFT- and BFT-treated animals compared to the disease control animals. This showed a correlation of free radicals and blast cells; however, this concept may require further study. Blood is an important index of physiological and pathological status in man persucum animals, and the parameters usually measured are differential leukocyte white blood cell count, RBC count, and platelet counts [20,21].

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In the present study, an imbalance in the persicim picture was observed under diseased conditions. After the treatment, the action performed by B. In summary, we have shown for the first time that B. These findings suggest and emphasize that ethyl acetate and butanol fractions from the seed extract of B. National Center for Biotechnology InformationU. Osong Public Health Res Perspect.

Published online Nov Author information Article notes Copyright and Persicm information Disclaimer.

This article has been cited by other articles in PMC. Abstract Objectives Humans have been using plants as natural medicines since prehistoric times.

Bunium persicum Black Caraway, Black Cumin PFAF Plant Database

Methods This study was performed on animals, which were divided into several groups: Results The ROS level and blast cells count were higher in disease control groups than in groups treated with varying amounts of B.

Conclusion Persiicum findings may indicate a possible link between free radicals and hematotoxicity and blast cells, while depicting a potential therapeutic role for B.

Bunium persicumhematotoxicity, ROS. Introduction Plants have been used as medicines since the dawn of civilization [1]. Materials and methods 2. Plant materials Plant materials seeds were purchased from a market in Rawalpindi, Pakistan. Ethical considerations This study was carried out with the approval and under the strict guidelines of the institutional ethics committee for the handling of animals.

Experimental design and treatment After the 40 th day of injection, the weight of each rat was accurately measured, and rats were treated as follows: Table 1 Treatment schedule. Group Treatment A Injected with leukemic blood; treated with aqueous fraction B Injected with leukemic blood; treated with butanol fraction C Designated as control group normal ; treated with 0. Open in a separate window. Hematological parameters After the treatment with plant differential extracts was completed, all rats were sacrificed on the 10 th day by decapitation, and blood was collected and sent to North Western Laboratory Peshawar, Pakistan, to determine the blood parameters: Collection of bone marrow The bone marrow was collected from the both the tibia and the femur within hours after the rats were sacrificed.

Hematological parameters and plant extracts Hematological parameters in various study groups treated with differential extracts of B. Table 2 Variation of differential blood parameters and comparative analysis of ROS mean values among normal control, disease control, and treated groups.

Effects of plant extracts on ROS level Elevated concentrations of free radicals are considered toxic for biological systems. Effects of plants extracts on blast cells Large numbers of blast cells were observed in the disease control group as compared with the normal control group.

Discussion Regulation of ROS level is essential for maintenance of normal populations of hematopoietic stem cells and their differentiation in normal hemopoetic cell lines [17,18]. Conflicts of interest None. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. Identification and conservation of important plant areas IPAs for the distribution of medicinal, aromatic and economic plants in the Hindukush—Himalaya mountain range.

A low volume, high price crop for dry temperate hills.